[Palmatine hydrochloride improves motor dysfunction in streptozotocin-induced diabetic rats]

Diabetes induces motor dysfunctions, Palmatine is an isoquinoline alkaloid, with anti-diabetic and antioxidant activities. This study was conducted to evaluate the effect of Palmatine on motor dysfunction in STZ-induced diabetic rats. In this experimental study, 32 male wistar rats were randomly allocated into control, Palmatine-treated non-diabetic, diabetic and Palmatine-treated diabetic groups. Diabetes was induced by STZ administration at the dose of 55 mg/kg/bw, intraperitoneally. Palmatine hydrochloride was administered subcutaneous at doses of 10 mg/kg/bw per day for a period of 6 weeks, one week after induction of diabetes. Blood glucose level was measured 1, 3, 5, 7 weeks after STZ injection. Locomotor activity tests including Y maze, grip-traction and inclined plane tests were performed to determining locomotor activity. In Y maze test, the number of arms entered significantly increased in Palmatine-treated diabetic group compared to diabetic group [P<0.05]. Grip traction and inclined plane tests significantly increased in Palmatine-treated diabetic group compared to diabetics animals [P<0.05]. Palmatine hydrochloride administration for 6 weeks improves motor dysfunctions in streptozotocin-induced diabetic rats

[Effect of palmatine hydrochloride on cognitive dysfunction in streptozotocin-induced diabetic rats]

Recent studies have shown that diabetes induced cognitive dysfunction and impairs learning and memory. Palmatine is an isoquinoline alkaloid, and has multiple pharmacological effects, including anti-diabetic and antioxidant activity. This study was conducted, to evaluate the effect of Palmatine on learning and spatial memory impairment in STZ-induced diabetic rats. This experimental study was conducted on the male Wistar rats [n=32] with approximate weight of 240 +/- 40 grams. The rats were randomly allocated and were divided into 4 groups [n=8]: Control, Palmatine-treated non-diabetic, diabetic and Palmatine-treated diabetic groups. Diabetes was induced by STZ administration at the dose of 55 mg/kg through intraperitoneal route. Palmatine hydrochloride was administered subcutaneous at doses of 10 mg/kg/day 1 week after STZ injection for a period of 6 weeks. Blood samples were taken from the tail vein 1, 3, 5, 7 weeks after STZ injection to measure blood glucose levels. Behavioral tests including spatial recognition and objective recognition were performed at the end of study. Data were analyzed by using Prism-5, one way ANOVA and Tukey tests. In spatial recognition test, the number of entrance in new arm of the Ymaze, in the Palmatinetreated groups significantly increased in compare to diabetic group in both sixth and seventh weeks [P<0.05]. Number of rearing in new arm significantly increased in sixth and seventh weeks, compare to the diabetic group [P<0.05]. The number of recognition novel objects in the Palmatine-treated diabetic group significantly increased in compare to diabetic group [P<0.05]. Palmatine hydrochloride administration for 6 weeks improves cognitive dysfunction in streptozotocin-induced diabetic rats